Can AI Beat Ageing?
Two bets on making old cells work like young ones. Life Biosciences uses Yamanaka's original genes and reached people first. NewLimit searches with a computer for genes that make cells younger without changing what kind of cell they are, which may be the more logical route, but logic is not proof. The search is paid for by insiders, years before any product, at a value its chief executive puts at about three point one billion dollars. Ordinary investors cannot get in yet.
Can AI beat ageing? NewLimit, co-founded by Coinbase CEO Brian Armstrong, is betting a computer search can find better genes for making old cells young than the ones behind a Nobel Prize. Its first target is old livers, not a longer life. NewLimit says the search found a medicine that made old mice recover from alcohol like young mice. NewLimit has not tested anything in people yet; it plans its first trial for 2027.
Sources checked for this episode (30)
- blog.newlimit.com/p/2026-may-june-progress-update
- youtube.com/watch?v=7K2fLbD2_Rg
- newlimit.com/science
- blog.newlimit.com/p/newlimit-raises-435m-led-by-founders
- clinicaltrials.gov/study/NCT07290244
- blog.newlimit.com/p/2025-year-in-review
- pubmed.ncbi.nlm.nih.gov/16904174/
- blog.newlimit.com/p/2024-year-in-review
- clinicaltrials.gov/api/v2/studies/NCT07290244
- doi.org/10.1016/j.cell.2018.01.029
- nobelprize.org/uploads/2018/06/advanced-medicineprize2012.pdf
- en.wikipedia.org/wiki/Ambrosia
- newlimit.com/therapeutics
- medlineplus.gov/liverdiseases.html
- blog.newlimit.com/p/2026-progress-update
- doi.org/10.1038/nature12586
- doi.org/10.1038/s43587-023-00528-5
- doi.org/10.1016/j.drudis.2024.104009
- altoslabs.com/featured/updates/altos-labs-launches-institute-...
- cira.kyoto-u.ac.jp/e/pressrelease/other/220119-160000.html
- blog.newlimit.com/p/announcing-newlimit-a-company-built
- sec.gov/Archives/edgar/data/1679788/000167978826000088/coin-2...
- blog.newlimit.com/p/newlimit-has-raised-an-additional
- blog.newlimit.com/p/newlimit-raises-130-million-series
- statnews.com/2026/06/02/longevity-startup-newlimit-announces-...
- sec.gov/Archives/edgar/data/707823/000003540226004656/primary...
- sec.gov/Archives/edgar/data/707823/000070782326000025/filing1...
- sec.gov/Archives/edgar/data/1708599/000170859924000033/ser-20...
- data.sec.gov/submissions/CIK0001708599.json
- blog.newlimit.com/p/newlimit-series-a