Is There Proof Ageing Can Be Undone?
The takeaway
Sinclair's theory made two predictions, and both held in mice: scramble the epigenetic tags and animals age faster, restore them and the clocks turn back. Tamed and gentle, the same genes have now reached people, with early signs that are a signal, not proof.
Can ageing be undone? David Sinclair's lab at Harvard set out to make mice age faster by scrambling the labels on DNA that tell each cell which genes to use. Then it tried to push those changes back with three of the four Yamanaka genes. In October 2026, Life Biosciences, which is testing the same three genes in people, reported early results from its first three patients.
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